Evaluation system and web infrastructure for the second cryo-EM model challenge

Andriy Kryshtafovych, Paul D. Adams, Catherine L. Lawson, Wah Chiu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


An evaluation system and a web infrastructure were developed for the second cryo-EM model challenge. The evaluation system includes tools to validate stereo-chemical plausibility of submitted models, check their fit to the corresponding density maps, estimate their overall and per-residue accuracy, and assess their similarity to reference cryo-EM or X-ray structures as well as other models submitted in this challenge. The web infrastructure provides a convenient interface for analyzing models at different levels of detail. It includes interactively sortable tables of evaluation scores for different subsets of models and different sublevels of structure organization, and a suite of visualization tools facilitating model analysis. The results are publicly accessible at http://model-compare.emdatabank.org.

Original languageAmerican English
Pages (from-to)96-108
Number of pages13
JournalJournal of Structural Biology
Issue number1
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Structural Biology


  • Cryo-EM
  • Model challenge
  • Protein structure modeling
  • Protein structure verification


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