Everyday action impairment in Parkinson's disease dementia

Tania Giovannetti, Priscilla Britnell, Laura Brennan, Andrew Siderowf, Murray Grossman, David J. Libon, Brianne M. Bettcher, Francesca Rouzard, Joel Eppig, Gregory A. Seidel

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors'an error type associated with executive control deficits.

Original languageEnglish (US)
Pages (from-to)787-798
Number of pages12
JournalJournal of the International Neuropsychological Society
Volume18
Issue number5
DOIs
StatePublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)

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