Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

Adaliene Versiani Matos Ferreira; Marcela Segatto; Zélia Menezes; Andréa Mara Macedo; Cláudio Gelape; Luciana de Oliveira Andrade; Fnu Nagajyothi; Philipp E. Scherer; Mauro Martins Teixeira; Herbert B. Tanowitz

doi:https://doi.org/10.1016/j.micinf.2011.06.002

Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

Adaliene Versiani Matos Ferreira, Marcela Segatto, Zélia Menezes, Andréa Mara Macedo, Cláudio Gelape, Luciana de Oliveira Andrade, Fnu Nagajyothi, Philipp E. Scherer, Mauro Martins Teixeira, Herbert B. Tanowitz

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.

Original language	English (US)
Pages (from-to)	1002-1005
Number of pages	4
Journal	Microbes and Infection
Volume	13
Issue number	12-13
DOIs	https://doi.org/10.1016/j.micinf.2011.06.002
State	Published - Nov 2011
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

Keywords

Adipocyte
Adipose tissue
Chagas disease
Trypanosoma cruzi

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https://doi.org/10.1016/j.micinf.2011.06.002

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@article{19749556af3e4b8eac247bf0c3ff649d,

title = "Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease",

abstract = "Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.",

keywords = "Adipocyte, Adipose tissue, Chagas disease, Trypanosoma cruzi",

author = "{Matos Ferreira}, {Adaliene Versiani} and Marcela Segatto and Z{\'e}lia Menezes and Macedo, {Andr{\'e}a Mara} and Cl{\'a}udio Gelape and {de Oliveira Andrade}, Luciana and Fnu Nagajyothi and Scherer, {Philipp E.} and Teixeira, {Mauro Martins} and Tanowitz, {Herbert B.}",

note = "Funding Information: This work was supported by a pilot grant from the Diabetes Research Center , Albert Einstein College of Medicine , and NIH Grant AI-76248 (HBT) and grants from Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnologico (CNPq, Brazil - MMT) and Funda{\c c}{\~a}o de Amparo a Pesquisas do Estado de Minas Gerais (FAPEMIG, Brazil- MMT) .",

year = "2011",

month = nov,

doi = "https://doi.org/10.1016/j.micinf.2011.06.002",

language = "English (US)",

volume = "13",

pages = "1002--1005",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "12-13",

}

TY - JOUR

T1 - Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

AU - Matos Ferreira, Adaliene Versiani

AU - Segatto, Marcela

AU - Menezes, Zélia

AU - Macedo, Andréa Mara

AU - Gelape, Cláudio

AU - de Oliveira Andrade, Luciana

AU - Nagajyothi, Fnu

AU - Scherer, Philipp E.

AU - Teixeira, Mauro Martins

AU - Tanowitz, Herbert B.

N1 - Funding Information: This work was supported by a pilot grant from the Diabetes Research Center , Albert Einstein College of Medicine , and NIH Grant AI-76248 (HBT) and grants from Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq, Brazil - MMT) and Fundação de Amparo a Pesquisas do Estado de Minas Gerais (FAPEMIG, Brazil- MMT) .

PY - 2011/11

Y1 - 2011/11

N2 - Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.

AB - Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.

KW - Adipocyte

KW - Adipose tissue

KW - Chagas disease

KW - Trypanosoma cruzi

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C2 - 21726660

SN - 1286-4579

VL - 13

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EP - 1005

JO - Microbes and Infection

JF - Microbes and Infection

IS - 12-13

ER -

Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

Abstract

ASJC Scopus subject areas

Keywords

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