Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative

Gary S. Goldberg, Alonso P. Moreno, John F. Bechberger, Stephen S. Hearn, Richard R. Shivers, Daniel J. Macphee, Yu Chun Zhang, Christian C.G. Naus

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

Glycyrrhetinic acid exhibits many pharmacological activities, including the ability to block gap junctional communication. However, the mechanism of glycyrrhetinic action is not clear. Others have shown that glycyrrhetinic acid apparently binds to a single proteinatious binding site in the plasma membrane. We present evidence that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques.

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalExperimental cell research
Volume222
Issue number1
DOIs
StatePublished - Jan 10 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

Fingerprint

Dive into the research topics of 'Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative'. Together they form a unique fingerprint.

Cite this