Experimental conduction block induced by serum from a patient with anti‐GM1 antibodies

Maria Santoro; Antonino Uncini; Massimo Corbo; Susan M. Staugaitis; Florian P. Thomas; Arthur P. Hays; Norman Latov

doi:10.1002/ana.410310407

Experimental conduction block induced by serum from a patient with anti‐GM1 antibodies

Maria Santoro
, Antonino Uncini
, Massimo Corbo
, Susan M. Staugaitis
, Florian P. Thomas
, Arthur P. Hays
, Norman Latov

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.

Original language	English
Pages (from-to)	385-390
Number of pages	6
Journal	Annals of Neurology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1002/ana.410310407
State	Published - Apr 1992

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

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10.1002/ana.410310407

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title = "Experimental conduction block induced by serum from a patient with anti‐GM1 antibodies",

abstract = "Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5\% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.",

author = "Maria Santoro and Antonino Uncini and Massimo Corbo and Staugaitis, \{Susan M.\} and Thomas, \{Florian P.\} and Hays, \{Arthur P.\} and Norman Latov",

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doi = "10.1002/ana.410310407",

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T1 - Experimental conduction block induced by serum from a patient with anti‐GM1 antibodies

AU - Santoro, Maria

AU - Uncini, Antonino

AU - Corbo, Massimo

AU - Staugaitis, Susan M.

AU - Thomas, Florian P.

AU - Hays, Arthur P.

AU - Latov, Norman

PY - 1992/4

Y1 - 1992/4

N2 - Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.

AB - Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.

UR - https://www.scopus.com/pages/publications/0026770640

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DO - 10.1002/ana.410310407

M3 - Article

C2 - 1586139

SN - 0364-5134

VL - 31

SP - 385

EP - 390

JO - Annals of Neurology

JF - Annals of Neurology

IS - 4

ER -

Experimental conduction block induced by serum from a patient with anti‐GM1 antibodies

Abstract

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