Experimental modulation and computational model of nano-hydrophobicity

Shuhuan Li, Shumei Zhai, Yin Liu, Hongyu Zhou, Jinmei Wu, Qing Jiao, Bin Zhang, Hao Zhu, Bing Yan

Research output: Contribution to journalArticlepeer-review


We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.

Original languageAmerican English
Pages (from-to)312-317
Number of pages6
Issue number1
StatePublished - 2015

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


  • Cytotoxicity
  • Gold
  • Hydrophilicity/hydrophobicity
  • Macrophages
  • Nanoparticle
  • Transmission electron microscopy (TEM)

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