TY - JOUR
T1 - Exploring temperature-responsive drug delivery with biocompatible fatty acids as phase change materials in ethyl cellulose nanofibers
AU - Wildy, Michael
AU - Wei, Wanying
AU - Xu, Kai
AU - Schossig, John
AU - Hu, Xiao
AU - la Cruz, David Salas de
AU - Hyun, Dong Choon
AU - Lu, Ping
N1 - Publisher Copyright: © 2024 Elsevier B.V.
PY - 2024/5
Y1 - 2024/5
N2 - This study introduces a novel temperature-responsive drug delivery system using ethyl cellulose (EC) nanofibers encapsulating a eutectic mixture of lauric acid/stearic acid (LA/SA) as phase change materials (PCMs) and Rhodamine B (RhB) as a model drug. Employing blend electrospinning, the nanofibers achieved controlled drug release responsive to temperature changes. The peak shift of the carbonyl group in FTIR analysis confirmed drug-polymer compatibility, while the absence of RhB peaks in the XRD and DSC assessments revealed RhB's amorphous distribution within the fibers. Our findings demonstrate that RhB release is dependent on its loading, with a slow initial release (<2 %) for 1 % and 5 % RhB loadings and a burst release (~12 %) for 10 % loading. Notably, the release rate was tunable at 37 °C by adjusting LA/SA concentration. The optimal LA/SA loading for temperature-responsive release is identified as 10 %. Over 240 h, there is a 32 % increase in RhB release at 37 °C, and an additional 8 % increase at 40 °C, compared to 25 °C. This research illustrates the potential of PCM-integrated nanofibers in smart drug delivery, particularly for chemotherapy, antibiotics, and anti-inflammatory drugs, showcasing an innovative approach to improving therapeutic efficiency while reducing side effects.
AB - This study introduces a novel temperature-responsive drug delivery system using ethyl cellulose (EC) nanofibers encapsulating a eutectic mixture of lauric acid/stearic acid (LA/SA) as phase change materials (PCMs) and Rhodamine B (RhB) as a model drug. Employing blend electrospinning, the nanofibers achieved controlled drug release responsive to temperature changes. The peak shift of the carbonyl group in FTIR analysis confirmed drug-polymer compatibility, while the absence of RhB peaks in the XRD and DSC assessments revealed RhB's amorphous distribution within the fibers. Our findings demonstrate that RhB release is dependent on its loading, with a slow initial release (<2 %) for 1 % and 5 % RhB loadings and a burst release (~12 %) for 10 % loading. Notably, the release rate was tunable at 37 °C by adjusting LA/SA concentration. The optimal LA/SA loading for temperature-responsive release is identified as 10 %. Over 240 h, there is a 32 % increase in RhB release at 37 °C, and an additional 8 % increase at 40 °C, compared to 25 °C. This research illustrates the potential of PCM-integrated nanofibers in smart drug delivery, particularly for chemotherapy, antibiotics, and anti-inflammatory drugs, showcasing an innovative approach to improving therapeutic efficiency while reducing side effects.
KW - Electrospinning
KW - Ethyl cellulose nanofibers
KW - Eutectic mixture
KW - Lauric acid
KW - Phase change material
KW - Rhodamine B
KW - Stearic acid
KW - Temperature-responsive drug delivery system
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U2 - 10.1016/j.ijbiomac.2024.131187
DO - 10.1016/j.ijbiomac.2024.131187
M3 - Article
C2 - 38552686
SN - 0141-8130
VL - 266
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 131187
ER -