Expression and regulation of a glutamate receptor subunit by bFGF in oligodendrocyte progenitors

Vittorio Gallo, Paul Wright, Randy Mckinnon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Oligodendrocyte progenitor cells (O‐2A) express both kainate‐preferring and AMPA‐preferring glutamate receptors (Gallo et al., Soc. Neurosci. Abstr., 18:653, 1992b; Gallo et al., 1994). The expression and regulation of the GluR‐4c, AMPA‐preferring subunit by growth factors was studied by Northern blot analysis of total RNA from purified rat cortical O‐2A progenitors. Differently from cortical neurons, O‐2A progenitors only expressed two high molecular weight GluR‐4c transcripts (6.2 and 4.2 kb), as observed also in cultured astrocytes. Basic fibroblast growth factor (bFGF) increased GluR‐4c transcript levels in O‐2A progenitors and its effects were not mimicked by platelet derived growth factor (PDGF) or fetal calf serum. Therefore, bFGF may regulate O‐2A progenitor responsiveness to glutamate during development through the expression of glutamate receptor subunits. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalGlia
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Oligodendroglia
Glutamate Receptors
Fibroblast Growth Factor 2
Platelet-Derived Growth Factor
Astrocytes
Northern Blotting
Glutamic Acid
Intercellular Signaling Peptides and Proteins
Stem Cells
Molecular Weight
RNA
Neurons
Serum

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience

Keywords

  • AMPA receptors
  • Glutamate channels
  • Growth factors
  • O‐2A progenitor cell

Cite this

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Expression and regulation of a glutamate receptor subunit by bFGF in oligodendrocyte progenitors. / Gallo, Vittorio; Wright, Paul; Mckinnon, Randy.

In: Glia, Vol. 10, No. 2, 01.01.1994, p. 149-153.

Research output: Contribution to journalArticle

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AB - Oligodendrocyte progenitor cells (O‐2A) express both kainate‐preferring and AMPA‐preferring glutamate receptors (Gallo et al., Soc. Neurosci. Abstr., 18:653, 1992b; Gallo et al., 1994). The expression and regulation of the GluR‐4c, AMPA‐preferring subunit by growth factors was studied by Northern blot analysis of total RNA from purified rat cortical O‐2A progenitors. Differently from cortical neurons, O‐2A progenitors only expressed two high molecular weight GluR‐4c transcripts (6.2 and 4.2 kb), as observed also in cultured astrocytes. Basic fibroblast growth factor (bFGF) increased GluR‐4c transcript levels in O‐2A progenitors and its effects were not mimicked by platelet derived growth factor (PDGF) or fetal calf serum. Therefore, bFGF may regulate O‐2A progenitor responsiveness to glutamate during development through the expression of glutamate receptor subunits. © 1994 Wiley‐Liss, Inc.

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