@inbook{c6efa42a3f2c47c18861cd710ce078bb,
title = "Extracellular matrix stiffness exists in a feedback loop that drives tumor progression",
abstract = "Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of the cell, including internal molecular signaling as well as behaviors such as motility and proliferation. Thus, cells and ECM interact in a feedback loop to drive matrix deposition and cross-linking, which alter the mechanical properties of the tissue. Stiffer tissue enhances the invasive potential of a tumor and decreases therapeutic efficacy. This chapter describes how specific molecular effects caused by an abnormally stiff tissue drive macroscopic changes that help determine disease outcome. A complete understanding may foster the generation of new cancer therapies.",
keywords = "Force, Mechanical stress, Morphodynamics",
author = "Simi, {Allison K.} and Pang, {Mei Fong} and Nelson, {Celeste M.}",
note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2018.",
year = "2018",
doi = "10.1007/978-3-319-95294-9_4",
language = "American English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "57--67",
booktitle = "Advances in Experimental Medicine and Biology",
}