Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1

Jennifer L. Goff, Jeffra K. Schaefer, Nathan Yee

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we investigated the extracellular reactive sulfur species produced by Shewanella oneidensis MR-1 during growth. The results showed that sulfite is the major extracellular sulfur metabolite released to the growth medium under both aerobic and anaerobic growth conditions. Exogenous sulfite at physiological concentrations protected S. oneidensis MR-1 from hydrogen peroxide toxicity and enhanced tolerance to the beta-lactam antibiotics cefazolin, meropenem, doripenem and ertapenem. These findings suggest that the release of extracellular sulfite is a bacterial defence mechanism that plays a role in the mitigation of environmental stress.

Original languageAmerican English
Pages (from-to)394-400
Number of pages7
JournalEnvironmental Microbiology Reports
Volume13
Issue number3
DOIs
StatePublished - Jun 2021

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)

Cite this