Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1

Jennifer L. Goff; Jeffra K. Schaefer; Nathan Yee

doi:https://doi.org/10.1111/1758-2229.12947

Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1

Jennifer L. Goff, Jeffra K. Schaefer, Nathan Yee

School of Environmental and Biological Sciences, Environmental Science

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we investigated the extracellular reactive sulfur species produced by Shewanella oneidensis MR-1 during growth. The results showed that sulfite is the major extracellular sulfur metabolite released to the growth medium under both aerobic and anaerobic growth conditions. Exogenous sulfite at physiological concentrations protected S. oneidensis MR-1 from hydrogen peroxide toxicity and enhanced tolerance to the beta-lactam antibiotics cefazolin, meropenem, doripenem and ertapenem. These findings suggest that the release of extracellular sulfite is a bacterial defence mechanism that plays a role in the mitigation of environmental stress.

Original language	American English
Pages (from-to)	394-400
Number of pages	7
Journal	Environmental Microbiology Reports
Volume	13
Issue number	3
DOIs	https://doi.org/10.1111/1758-2229.12947
State	Published - Jun 2021

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Agricultural and Biological Sciences (miscellaneous)

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title = "Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1",

abstract = "In this study, we investigated the extracellular reactive sulfur species produced by Shewanella oneidensis MR-1 during growth. The results showed that sulfite is the major extracellular sulfur metabolite released to the growth medium under both aerobic and anaerobic growth conditions. Exogenous sulfite at physiological concentrations protected S. oneidensis MR-1 from hydrogen peroxide toxicity and enhanced tolerance to the beta-lactam antibiotics cefazolin, meropenem, doripenem and ertapenem. These findings suggest that the release of extracellular sulfite is a bacterial defence mechanism that plays a role in the mitigation of environmental stress.",

author = "Goff, {Jennifer L.} and Schaefer, {Jeffra K.} and Nathan Yee",

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AB - In this study, we investigated the extracellular reactive sulfur species produced by Shewanella oneidensis MR-1 during growth. The results showed that sulfite is the major extracellular sulfur metabolite released to the growth medium under both aerobic and anaerobic growth conditions. Exogenous sulfite at physiological concentrations protected S. oneidensis MR-1 from hydrogen peroxide toxicity and enhanced tolerance to the beta-lactam antibiotics cefazolin, meropenem, doripenem and ertapenem. These findings suggest that the release of extracellular sulfite is a bacterial defence mechanism that plays a role in the mitigation of environmental stress.

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Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1

Abstract

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