EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Sergey Karakashev; Takeshi Fukumoto; Bo Zhao; Jianhuang Lin; Shuai Wu; Nail Fatkhutdinov; Pyoung Hwa Park; Galina Semenova; Stephanie Jean; Mark G. Cadungog; Mark E. Borowsky; Andrew V. Kossenkov; Qin Liu; Rugang Zhang

doi:10.1016/j.ccell.2019.12.015

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Sergey Karakashev, Takeshi Fukumoto, Bo Zhao, Jianhuang Lin, Shuai Wu, Nail Fatkhutdinov, Pyoung Hwa Park, Galina Semenova, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Andrew V. Kossenkov, Qin Liu, Rugang Zhang

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

Original language	English
Pages (from-to)	157-167.e6
Journal	Cancer Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.ccell.2019.12.015
State	Published - Feb 10 2020

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

Keywords

BAF155
CARM1
EZH2 inhibitors
MAD2L2 (REV7)
PARP inhibitors
SWI/SNF
epithelial ovarian cancer
homologous recombination (HR)
non-homologous end-joining (NHEJ)
polycomb repressive complex 2 (PRC2)
shieldin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2019.12.015

Cite this

Karakashev, S., Fukumoto, T., Zhao, B., Lin, J., Wu, S., Fatkhutdinov, N., Park, P. H., Semenova, G., Jean, S., Cadungog, M. G., Borowsky, M. E., Kossenkov, A. V., Liu, Q., & Zhang, R. (2020). EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. Cancer Cell, 37(2), 157-167.e6. https://doi.org/10.1016/j.ccell.2019.12.015

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title = "EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition",

abstract = "Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.",

keywords = "BAF155, CARM1, EZH2 inhibitors, MAD2L2 (REV7), PARP inhibitors, SWI/SNF, epithelial ovarian cancer, homologous recombination (HR), non-homologous end-joining (NHEJ), polycomb repressive complex 2 (PRC2), shieldin",

author = "Sergey Karakashev and Takeshi Fukumoto and Bo Zhao and Jianhuang Lin and Shuai Wu and Nail Fatkhutdinov and Park, {Pyoung Hwa} and Galina Semenova and Stephanie Jean and Cadungog, {Mark G.} and Borowsky, {Mark E.} and Kossenkov, {Andrew V.} and Qin Liu and Rugang Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

day = "10",

doi = "10.1016/j.ccell.2019.12.015",

language = "English",

volume = "37",

pages = "157--167.e6",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "2",

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TY - JOUR

T1 - EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

AU - Karakashev, Sergey

AU - Fukumoto, Takeshi

AU - Zhao, Bo

AU - Lin, Jianhuang

AU - Wu, Shuai

AU - Fatkhutdinov, Nail

AU - Park, Pyoung Hwa

AU - Semenova, Galina

AU - Jean, Stephanie

AU - Cadungog, Mark G.

AU - Borowsky, Mark E.

AU - Kossenkov, Andrew V.

AU - Liu, Qin

AU - Zhang, Rugang

PY - 2020/2/10

Y1 - 2020/2/10

N2 - Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

AB - Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

KW - BAF155

KW - CARM1

KW - EZH2 inhibitors

KW - MAD2L2 (REV7)

KW - PARP inhibitors

KW - SWI/SNF

KW - epithelial ovarian cancer

KW - homologous recombination (HR)

KW - non-homologous end-joining (NHEJ)

KW - polycomb repressive complex 2 (PRC2)

KW - shieldin

UR - http://www.scopus.com/inward/record.url?scp=85078833277&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2019.12.015

DO - 10.1016/j.ccell.2019.12.015

M3 - Article

C2 - 32004442

SN - 1535-6108

VL - 37

SP - 157-167.e6

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Abstract

ASJC Scopus subject areas

Keywords

UN SDGs

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