EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Sergey Karakashev; Takeshi Fukumoto; Bo Zhao; Jianhuang Lin; Shuai Wu; Nail Fatkhutdinov; Pyoung Hwa Park; Galina Semenova; Stephanie Jean; Mark G. Cadungog; Mark E. Borowsky; Andrew V. Kossenkov; Qin Liu; Rugang Zhang

doi:10.1016/j.ccell.2019.12.015

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Sergey Karakashev
, Takeshi Fukumoto
, Bo Zhao
, Jianhuang Lin
, Shuai Wu
, Nail Fatkhutdinov
, Pyoung Hwa Park
, Galina Semenova
, Stephanie Jean
, Mark G. Cadungog
, Mark E. Borowsky
, Andrew V. Kossenkov
, Qin Liu
, Rugang Zhang

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

Original language	English
Pages (from-to)	157-167.e6
Journal	Cancer Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.ccell.2019.12.015
State	Published - Feb 10 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

Keywords

BAF155
CARM1
EZH2 inhibitors
MAD2L2 (REV7)
PARP inhibitors
SWI/SNF
epithelial ovarian cancer
homologous recombination (HR)
non-homologous end-joining (NHEJ)
polycomb repressive complex 2 (PRC2)
shieldin

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10.1016/j.ccell.2019.12.015

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Karakashev, S., Fukumoto, T., Zhao, B., Lin, J., Wu, S., Fatkhutdinov, N., Park, P. H., Semenova, G., Jean, S., Cadungog, M. G., Borowsky, M. E., Kossenkov, A. V., Liu, Q., & Zhang, R. (2020). EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. Cancer Cell, 37(2), 157-167.e6. https://doi.org/10.1016/j.ccell.2019.12.015

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title = "EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition",

abstract = "Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.",

keywords = "BAF155, CARM1, EZH2 inhibitors, MAD2L2 (REV7), PARP inhibitors, SWI/SNF, epithelial ovarian cancer, homologous recombination (HR), non-homologous end-joining (NHEJ), polycomb repressive complex 2 (PRC2), shieldin",

author = "Sergey Karakashev and Takeshi Fukumoto and Bo Zhao and Jianhuang Lin and Shuai Wu and Nail Fatkhutdinov and Park, \{Pyoung Hwa\} and Galina Semenova and Stephanie Jean and Cadungog, \{Mark G.\} and Borowsky, \{Mark E.\} and Kossenkov, \{Andrew V.\} and Qin Liu and Rugang Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

day = "10",

doi = "10.1016/j.ccell.2019.12.015",

language = "English",

volume = "37",

pages = "157--167.e6",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "2",

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TY - JOUR

T1 - EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

AU - Karakashev, Sergey

AU - Fukumoto, Takeshi

AU - Zhao, Bo

AU - Lin, Jianhuang

AU - Wu, Shuai

AU - Fatkhutdinov, Nail

AU - Park, Pyoung Hwa

AU - Semenova, Galina

AU - Jean, Stephanie

AU - Cadungog, Mark G.

AU - Borowsky, Mark E.

AU - Kossenkov, Andrew V.

AU - Liu, Qin

AU - Zhang, Rugang

PY - 2020/2/10

Y1 - 2020/2/10

N2 - Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

AB - Karakashev et al. show that CARM1 promotes EZH2-mediated epigenetic silencing of the shieldin complex protein MAD2L2. Inhibition of EZH2 induces MAD2L2 expression and non-homologous end-joining in CARM1-high, homologous recombination proficient ovarian carcinoma cells, sensitizing them to PARP inhibitors.

KW - BAF155

KW - CARM1

KW - EZH2 inhibitors

KW - MAD2L2 (REV7)

KW - PARP inhibitors

KW - SWI/SNF

KW - epithelial ovarian cancer

KW - homologous recombination (HR)

KW - non-homologous end-joining (NHEJ)

KW - polycomb repressive complex 2 (PRC2)

KW - shieldin

UR - https://www.scopus.com/pages/publications/85078833277

U2 - 10.1016/j.ccell.2019.12.015

DO - 10.1016/j.ccell.2019.12.015

M3 - Article

C2 - 32004442

SN - 1535-6108

VL - 37

SP - 157-167.e6

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Abstract

UN SDGs

ASJC Scopus subject areas

Keywords

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