Fibronectin-fibrin cross-linking

A regulator of cell behavior

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

At sites of tissue injury or inflammation, extravasation of plasma proteins leads to the formation of a complex fibrillar matrix composed primarily of fibrin and plasma fibronectin (pFN). This protein meshwork serves not only to reestablish the integrity of the vascular system but also to provide a scaffold for cell migration and subsequent wound repair. The interactions between cell surface receptors and this provisional extracellular matrix (ECM) provide important cues that can modulate the cellular response at the injury site, leading to alterations in cell growth and gene expression. Key determinants of this response may lie in the structure and composition of this 'injury-associated' ECM.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume8
Issue number8
DOIs
StatePublished - Jan 1 1998

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Fibrin
Fibronectins
Wounds and Injuries
Extracellular Matrix
Cell Surface Receptors
Cell Movement
Cues
Blood Vessels
Blood Proteins
Inflammation
Gene Expression
Growth
Proteins

Cite this

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Fibronectin-fibrin cross-linking : A regulator of cell behavior. / Corbett, Siobhan; Schwarzbauer, Jean E.

In: Trends in Cardiovascular Medicine, Vol. 8, No. 8, 01.01.1998, p. 357-362.

Research output: Contribution to journalArticle

TY - JOUR

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