First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine

Liang Chen, Nahed Al Laham, Kalyan D. Chavda, Jose R. Mediavilla, Michael R. Jacobs, Robert A. Bonomo, Barry N. Kreiswirth

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the blaOXA-48-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene blaOXA-48, extended spectrum β-lactamase gene blaCTX-M-14, and aminoglycoside resistance genes strA, strB, and aph(3′)-VIb.

Original languageEnglish (US)
Pages (from-to)4305-4307
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume59
Issue number7
DOIs
StatePublished - Jul 1 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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