Five-lipoxygenase pathway of arachidonic acid metabolism in carcinogenesis and cancer chemoprevention

Xiaoxin Chen, Sandeep Sood, Chung S. Yang, Ning Li, Zheng Sun

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Aberrant arachidonic acid metabolism has recently received intensive attention in the field of cancer research. Recent discoveries regarding the long-term cardiovascular side effects of cyclooxygenase 2 inhibitors have cast doubts on their use for cancer chemoprevention. Although such a problem does not undermine the importance of cyclooxygenase 2 as a cancer chemopreventive target, investigation into other AA-metabolizing pathways that are also important in inflammation and inflammation-associated carcinogenesis is necessary. Here, the important role of the 5-lipoxygenase pathway in carcinogenesis is reviewed. Inhibition of the 5-lipoxygenase pathways clearly has chemopreventive effects on various cancers, and hence further studies on its enzymes, metabolites and receptors for cancer chemoprevention and therapy are warranted.

Original languageEnglish (US)
Pages (from-to)613-622
Number of pages10
JournalCurrent Cancer Drug Targets
Volume6
Issue number7
DOIs
StatePublished - Nov 2006

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Oncology
  • Cancer Research
  • Pharmacology

Keywords

  • 5-Lipoxygenase
  • Cancer
  • Leukotrienes

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