Flavonoid glycosides from microtea debilis and their cytotoxic and anti-inflammatory effects

Naisheng Bai, Kan He, Marc Roller, Ching Shu Lai, Xi Shao, Min Hsiung Pan, Antoine Bily, Chi-Tang Ho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two new 5-O-glucosylflavones, 5-O-β-D-glucopyranosyl cirsimaritin (1) and 5, 4'-O-β-Ddiglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7- methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 7.1, 13.1, 6.1, and 6.8 μM, respectively.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalFitoterapia
Volume82
Issue number2
DOIs
StatePublished - Jan 1 2011

Fingerprint

Glycosides
Flavonoids
Anti-Inflammatory Agents
Macrophages
Norisoprenoids
Hep G2 Cells
Nitrites
cirsimaritin
Neoplasms

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology

Keywords

  • 5,4'-O-β-D-Diglucopyranosyl cirsimaritin
  • 5-O-β-D-Glucopyranosyl cirsimaritin
  • Anti-inflammatory
  • Human cancer cell lines (Hep G2, COLO 205, HL-60)
  • Microtea debilis

Cite this

Bai, Naisheng ; He, Kan ; Roller, Marc ; Lai, Ching Shu ; Shao, Xi ; Pan, Min Hsiung ; Bily, Antoine ; Ho, Chi-Tang. / Flavonoid glycosides from microtea debilis and their cytotoxic and anti-inflammatory effects. In: Fitoterapia. 2011 ; Vol. 82, No. 2. pp. 168-172.
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Flavonoid glycosides from microtea debilis and their cytotoxic and anti-inflammatory effects. / Bai, Naisheng; He, Kan; Roller, Marc; Lai, Ching Shu; Shao, Xi; Pan, Min Hsiung; Bily, Antoine; Ho, Chi-Tang.

In: Fitoterapia, Vol. 82, No. 2, 01.01.2011, p. 168-172.

Research output: Contribution to journalArticle

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