Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors

Shengguo Li, Zeqian Mo, Xuejie Yang, Sandy M. Price, Michael M. Shen, Mengqing Xiang

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

During vertebrate retinogenesis, seven classes of cells are specified from multipotent progenitors. To date, the mechanisms underlying multipotent cell fate determination by retinal progenitors remain poorly understood. Here, we show that the Foxn4 winged helix/forkhead transcription factor is expressed in a subset of mitotic progenitors during mouse retinogenesis. Targeted disruption of Foxn4 largely eliminates amacrine neurons and completely abolishes horizontal cells, while overexpression of Foxn4 strongly promotes an amacrine cell fate. These results indicate that Foxn4 is both necessary and sufficient for commitment to the amacrine cell fate and is nonredundantly required for the genesis of horizontal cells. Furthermore, we provide evidence that Foxn4 controls the formation of amacrine and horizontal cells by activating the expression of the retinogenic factors Math3, NeuroD1, and Prox1. Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors.

Original languageEnglish (US)
Pages (from-to)795-807
Number of pages13
JournalNeuron
Volume43
Issue number6
DOIs
StatePublished - Sep 16 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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