Frequency analysis of the sleep EEG in depression

Wallace B. Mendelson, David A. Sack, Steven P. James, Joseph V. Martin, Richard Wagner, Debra Garnett, John Milton, Thomas A. Wehr

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Eight patients with major depressive disorder (seven bipolar and one unipolar) and matched controls had sleep studies, on which frequency analysis of the electroencephalogram (EEG) was performed. Total sleep and sleep efficiency were decreased in the patients, but there was no significant difference in rapid eye movement (REM) latency between the two groups. Frequency analysis revealed no group differences in power in the delta band (0.23-2.5 Hz) or the whole EEG spectrum (0.23-25 Hz). These findings suggest that mean REM latencies are not always shorter in major depression. The results are discussed in light of a previous report of decreased delta energy in the sleep EEG of unipolar patients.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalPsychiatry Research
Issue number2
StatePublished - Jun 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry


  • Sleep
  • electroencephalogram
  • frequency analysis


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