Functional Heterogeneity in the Basophil Cell Lineage

Mark C. Siracusa, Elia D.Tait Wojno, David Artis

Research output: Chapter in Book/Report/Conference proceedingChapter

31 Scopus citations


CD4 + T-helper type 2 (Th2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9, and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases. Recent reports from a number of laboratories have indicated that basophils can influence the induction and/or effector stages of Th2 cytokine-mediated inflammation. However, the impact of basophils appears to depend on the anatomical location and nature of the infectious or inflammatory stimulus. This review highlights the factors that regulate basophil development and activation and describes known basophil effector functions. Further, we discuss the recent identification of phenotypic and functional heterogeneity within murine and human basophil populations and discuss how these findings may explain the context-dependent influence of basophils on either the propagation, regulation, or effector phases of Th2 cytokine-associated inflammation.

Original languageEnglish (US)
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Number of pages19
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Immunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


  • Basophils
  • IgE
  • Mast cells


Dive into the research topics of 'Functional Heterogeneity in the Basophil Cell Lineage'. Together they form a unique fingerprint.

Cite this