Functional insights from structural genomics

Farhad Forouhar, Alexandre Kuzin, Jayaraman Seetharaman, Insun Lee, Weihong Zhou, Mariam Abashidze, Yang Chen, Wei Yong, Haleema Janjua, Yingyi Fang, Dongyan Wang, Kellie Cunningham, Rong Xiao, Thomas B. Acton, Eran Pichersky, Daniel F. Klessig, Carl W. Porter, Gaetano T. Montelione, Liang Tong

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF_0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP_1951), and a 12-stranded β-barrel with a novel fold (V. parahaemolyticus VPA1032).

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of Structural and Functional Genomics
Volume8
Issue number2-3
DOIs
StatePublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Genetics
  • Structural Biology
  • Biochemistry

Keywords

  • Acetyltransferase
  • Methyltransferase
  • Spermine

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