Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses

Sabine Kienesberger, Laura M. Cox, Alexandra Livanos, Xue Song Zhang, Jennifer Chung, Guillermo I. Perez-Perez, Gregor Gorkiewicz, Ellen L. Zechner, Martin J. Blaser

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.

Original languageEnglish (US)
Pages (from-to)1395-1407
Number of pages13
JournalCell Reports
Volume14
Issue number6
DOIs
StatePublished - Feb 16 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kienesberger, S., Cox, L. M., Livanos, A., Zhang, X. S., Chung, J., Perez-Perez, G. I., Gorkiewicz, G., Zechner, E. L., & Blaser, M. J. (2016). Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses. Cell Reports, 14(6), 1395-1407. https://doi.org/10.1016/j.celrep.2016.01.017