Genetic and biochemical analysis of TGFβ signal transduction

TY - JOUR

T1 - Genetic and biochemical analysis of TGFβ signal transduction

AU - Padgett, Richard W.

AU - Savage, Cathy

AU - Das, Pradeep

PY - 1997/3

Y1 - 1997/3

N2 - TGFβ-like ligands are involved in many different developmental processes that pattern a variety of tissues in invertebrates and vertebrates. In the last few years, rapid progress has been made toward elucidating the developmental roles of the TGFβ-like pathways and identifying the novel components involved in transducing their signals, particularly the newly discovered Smads. This rapid progress has been the result of a synergy between classical genetic approaches and biochemical approaches, and this combined approach is likely to propel future understanding of the signaling pathway use by TGFβ.

AB - TGFβ-like ligands are involved in many different developmental processes that pattern a variety of tissues in invertebrates and vertebrates. In the last few years, rapid progress has been made toward elucidating the developmental roles of the TGFβ-like pathways and identifying the novel components involved in transducing their signals, particularly the newly discovered Smads. This rapid progress has been the result of a synergy between classical genetic approaches and biochemical approaches, and this combined approach is likely to propel future understanding of the signaling pathway use by TGFβ.

KW - Caenorhabditis elegans

KW - Drosophila

KW - Signal transduction

KW - Smad proteins

KW - TGFβ

UR - http://www.scopus.com/inward/record.url?scp=0031105218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031105218&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/S1359-6101(96)00050-0

DO - https://doi.org/10.1016/S1359-6101(96)00050-0

M3 - Short survey

C2 - 9174659

SN - 1359-6101

VL - 8

SP - 1

EP - 9

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 1

ER -