Genetic and biochemical analysis of TGFβ signal transduction

Richard W. Padgett, Cathy Savage, Pradeep Das

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


TGFβ-like ligands are involved in many different developmental processes that pattern a variety of tissues in invertebrates and vertebrates. In the last few years, rapid progress has been made toward elucidating the developmental roles of the TGFβ-like pathways and identifying the novel components involved in transducing their signals, particularly the newly discovered Smads. This rapid progress has been the result of a synergy between classical genetic approaches and biochemical approaches, and this combined approach is likely to propel future understanding of the signaling pathway use by TGFβ.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCytokine and Growth Factor Reviews
Issue number1
StatePublished - Mar 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


  • Caenorhabditis elegans
  • Drosophila
  • Signal transduction
  • Smad proteins
  • TGFβ


Dive into the research topics of 'Genetic and biochemical analysis of TGFβ signal transduction'. Together they form a unique fingerprint.

Cite this