Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity

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Abstract

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed.

Original languageEnglish (US)
Pages (from-to)759-762
Number of pages4
JournalEnvironmental health perspectives
Volume105
Issue numberSUPPL. 4
DOIs
StatePublished - Jun 1997

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Keywords

  • Biomarker
  • Cancer risk
  • Cytochrome P450
  • Environmental toxicity
  • Genetic polymorphisms
  • Metabolism
  • Susceptibility

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