Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Original languageEnglish (US)
Article numbere1006528
JournalPLoS genetics
Volume13
Issue number4
DOIs
StatePublished - Apr 2017

Fingerprint

physical activity
Adiposity
meta-analysis
adiposity
Meta-Analysis
genome
Genome
Obesity
Waist-Hip Ratio
Genetic Association Studies
Waist Circumference
loci
obesity
Genes
waist
gene
waist circumference
hips
ancestry
environmental factor

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Cancer Research

Cite this

CHARGE Consortium ; EPIC-InterAct Consortium ; PAGE Consortium. / Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. In: PLoS genetics. 2017 ; Vol. 13, No. 4.
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abstract = "Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23{\%} of participants were categorized as inactive and 77{\%} as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30{\%} in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.",
author = "{CHARGE Consortium} and {EPIC-InterAct Consortium} and {PAGE Consortium} and Mariaelisa Graff and Scott, {Robert A.} and Justice, {Anne E.} and Young, {Kristin L.} and Feitosa, {Mary F.} and Llilda Barata and Winkler, {Thomas W.} and Chu, {Audrey Y.} and Anubha Mahajan and David Hadley and Luting Xue and Tsegaselassie Workalemahu and Heard-Costa, {Nancy L.} and {den Hoed}, Marcel and Ahluwalia, {Tarunveer S.} and Qibin Qi and Ngwa, {Julius S.} and Frida Renstr{\"o}m and Lydia Quaye and Eicher, {John D.} and Hayes, {James E.} and Marilyn Cornelis and Zoltan Kutalik and Elise Lim and Jian’an Luan and Huffman, {Jennifer E.} and Weihua Zhang and Wei Zhao and Griffin, {Paula J.} and Toomas Haller and Shafqat Ahmad and Marques-Vidal, {Pedro M.} and Stephanie Bien and Loic Yengo and Alexander Teumer and Smith, {Albert Vernon} and Meena Kumari and Harder, {Marie Neergaard} and Justesen, {Johanne Marie} and Kleber, {Marcus E.} and Mette Hollensted and Kurt Lohman and Rivera, {Natalia V.} and Whitfield, {John B.} and Zhao, {Jing Hua} and Stringham, {Heather M.} and Lyytik{\"a}inen, {Leo Pekka} and Charlotte Huppertz and Gonneke Willemsen and Peyrot, {Wouter J.}",
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CHARGE Consortium, EPIC-InterAct Consortium & PAGE Consortium 2017, 'Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults', PLoS genetics, vol. 13, no. 4, e1006528. https://doi.org/10.1371/journal.pgen.1006528

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. / CHARGE Consortium; EPIC-InterAct Consortium; PAGE Consortium.

In: PLoS genetics, Vol. 13, No. 4, e1006528, 04.2017.

Research output: Contribution to journalArticle

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AU - CHARGE Consortium

AU - EPIC-InterAct Consortium

AU - PAGE Consortium

AU - Graff, Mariaelisa

AU - Scott, Robert A.

AU - Justice, Anne E.

AU - Young, Kristin L.

AU - Feitosa, Mary F.

AU - Barata, Llilda

AU - Winkler, Thomas W.

AU - Chu, Audrey Y.

AU - Mahajan, Anubha

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AU - Workalemahu, Tsegaselassie

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AU - Quaye, Lydia

AU - Eicher, John D.

AU - Hayes, James E.

AU - Cornelis, Marilyn

AU - Kutalik, Zoltan

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AU - Luan, Jian’an

AU - Huffman, Jennifer E.

AU - Zhang, Weihua

AU - Zhao, Wei

AU - Griffin, Paula J.

AU - Haller, Toomas

AU - Ahmad, Shafqat

AU - Marques-Vidal, Pedro M.

AU - Bien, Stephanie

AU - Yengo, Loic

AU - Teumer, Alexander

AU - Smith, Albert Vernon

AU - Kumari, Meena

AU - Harder, Marie Neergaard

AU - Justesen, Johanne Marie

AU - Kleber, Marcus E.

AU - Hollensted, Mette

AU - Lohman, Kurt

AU - Rivera, Natalia V.

AU - Whitfield, John B.

AU - Zhao, Jing Hua

AU - Stringham, Heather M.

AU - Lyytikäinen, Leo Pekka

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AU - Peyrot, Wouter J.

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