Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City

Brandon Eilertson, Liang Chen, Kalyan D. Chavda, Barry N. Kreiswirth

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K. michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

Original languageEnglish (US)
Article numbere02458-16
JournalAntimicrobial agents and chemotherapy
Volume61
Issue number4
DOIs
StatePublished - Apr 2017

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

Keywords

  • CRE
  • Carbapenems
  • KPC
  • Tn4401b

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