Cafe au lait spots from eight patients presumed to have neurofibromatosis were evaluated for giant pigment granules (GPGs) by light microscope examination of dihydroxyphenylalanine (dopa)-incubated epidermal whole-mount specimens and by light microscope examination of tissue sections. Giant pigment granules were found in six of eight of the dopa-incubated epidermal whole-mount specimens and in all eight of the paraffin-embedded specimens sectioned and stained with hematoxylin-eosin. Our findings suggest that routine biopsy preparations can be used to identify GPGs. This should facilitate studies of the incidence and significance of GPGs in cafe au lait spots.
|Original language||English (US)|
|Number of pages||4|
|Journal||Archives of dermatology|
|State||Published - Jun 1982|
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