Giant Pigment Granules in Biopsy Specimens From Cafe au Lait Spots in Neurofibromatosis

Thomas J. Morris; William G. Johnson; David N. Silvers

doi:https://doi.org/10.1001/archderm.1982.01650180019009

Giant Pigment Granules in Biopsy Specimens From Cafe au Lait Spots in Neurofibromatosis

Thomas J. Morris, William G. Johnson, David N. Silvers

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cafe au lait spots from eight patients presumed to have neurofibromatosis were evaluated for giant pigment granules (GPGs) by light microscope examination of dihydroxyphenylalanine (dopa)-incubated epidermal whole-mount specimens and by light microscope examination of tissue sections. Giant pigment granules were found in six of eight of the dopa-incubated epidermal whole-mount specimens and in all eight of the paraffin-embedded specimens sectioned and stained with hematoxylin-eosin. Our findings suggest that routine biopsy preparations can be used to identify GPGs. This should facilitate studies of the incidence and significance of GPGs in cafe au lait spots.

Original language	English (US)
Pages (from-to)	385-388
Number of pages	4
Journal	Archives of dermatology
Volume	118
Issue number	6
DOIs	https://doi.org/10.1001/archderm.1982.01650180019009
State	Published - Jun 1982
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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title = "Giant Pigment Granules in Biopsy Specimens From Cafe au Lait Spots in Neurofibromatosis",

abstract = "Cafe au lait spots from eight patients presumed to have neurofibromatosis were evaluated for giant pigment granules (GPGs) by light microscope examination of dihydroxyphenylalanine (dopa)-incubated epidermal whole-mount specimens and by light microscope examination of tissue sections. Giant pigment granules were found in six of eight of the dopa-incubated epidermal whole-mount specimens and in all eight of the paraffin-embedded specimens sectioned and stained with hematoxylin-eosin. Our findings suggest that routine biopsy preparations can be used to identify GPGs. This should facilitate studies of the incidence and significance of GPGs in cafe au lait spots.",

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AB - Cafe au lait spots from eight patients presumed to have neurofibromatosis were evaluated for giant pigment granules (GPGs) by light microscope examination of dihydroxyphenylalanine (dopa)-incubated epidermal whole-mount specimens and by light microscope examination of tissue sections. Giant pigment granules were found in six of eight of the dopa-incubated epidermal whole-mount specimens and in all eight of the paraffin-embedded specimens sectioned and stained with hematoxylin-eosin. Our findings suggest that routine biopsy preparations can be used to identify GPGs. This should facilitate studies of the incidence and significance of GPGs in cafe au lait spots.

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Giant Pigment Granules in Biopsy Specimens From Cafe au Lait Spots in Neurofibromatosis

Abstract

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