Graphical process design tools for iontophoretic transdermal drug-delivery devices

Research output: Contribution to journalArticle

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Abstract

A graphical procedure was proposed for the optimum design of transdermal drug-delivery systems enhanced by iontophoresis. Contour plots displayed the relationships among steady-state plasma level, current density and initial drug concentration in a vehicle. This information was combined with a closed-form expression of the process time constant, estimated as the medicament in the blood reaches a plateau after application of the electric field. Analysis was conducted using Laplace-transformed variables and did not require time-domain solutions. Simulation results show that a current density of 0.044mA/cm2 and a loading of 3500μg/ml of dexamethasone sodium m-sulfobenzoate were necessary to achieve an equilibrium plasma concentration of 1.254ng/cm3 with a time constant of 8.34h.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalComputer Methods and Programs in Biomedicine
Volume107
Issue number3
DOIs
StatePublished - Sep 1 2012

All Science Journal Classification (ASJC) codes

  • Software
  • Health Informatics
  • Computer Science Applications

Keywords

  • Iontophoresis
  • Membrane transport
  • Optimum design
  • Simulations
  • Time constant
  • Transdermal drug delivery

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