Heat and radiation sensitivity of chinese hamster V79 cells and of nine clones selected from survivors of a thermal tolerant cell population

G. Peter Raaphorst, Edouard I. Azzam

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Chinese hamster V 79 cells heated for 12 hours at 42°C. Surviving cells were cloned and grown as separate cell lines. Nine clones were tested for heat and/or X ray sensitivity after three weeks. Heat sensitivity to 42°C or 45°C was the same as the parent cell line. Also, the radiation sensitivity and response to the combined effects of heat and radiation remained unchanged compared to the original V 79 cell line. Thus, no thermal mutants were selected in the thermal tolerant cell population and the thermal shock received by survivors did not permanently alter the response to heat and/or X rays.

Original languageEnglish (US)
Pages (from-to)1577-1581
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume6
Issue number11
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Keywords

  • Clones
  • Hyperthermia
  • Thermal tolerance

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