Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

Niall P. Murphy, Hoa A. Lam, Zhenping Chen, John E. Pintar, Nigel T. Maidment

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalBrain Research
Volume953
Issue number1-2
DOIs
StatePublished - Nov 20 2002

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Dopamine
  • Locomotion
  • Mesolimbic
  • Nociceptin
  • Opiate
  • Orphanin FQ

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