Highly structured water network in crystals of a deoxydinucleoside-drug complex

Stephen Neidle, Helen M. Berman, H. S. Shieh

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-Å intervals. The conformation of the deoxyribose sugar ring at the 3′ end of one strand can depend on its local aqueous environment.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalNature
Volume288
Issue number5787
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • General

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