Highly structured water network in crystals of a deoxydinucleoside-drug complex

TY - JOUR

T1 - Highly structured water network in crystals of a deoxydinucleoside-drug complex

AU - Neidle, Stephen

AU - Berman, Helen M.

AU - Shieh, H. S.

PY - 1980

Y1 - 1980

N2 - X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-Å intervals. The conformation of the deoxyribose sugar ring at the 3′ end of one strand can depend on its local aqueous environment.

AB - X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-Å intervals. The conformation of the deoxyribose sugar ring at the 3′ end of one strand can depend on its local aqueous environment.

UR - http://www.scopus.com/inward/record.url?scp=0019323773&partnerID=8YFLogxK

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U2 - https://doi.org/10.1038/288129a0

DO - https://doi.org/10.1038/288129a0

M3 - Article

C2 - 7432511

VL - 288

SP - 129

EP - 133

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5787

ER -