Abstract
The chromosome passenger complex (CPC) localizes to chromosomes and microtubules, sometimes simultaneously. The CPC also has multiple domains for interacting with chromatin and microtubules. Interactions between the CPC and both the chromatin and microtubules is important for spindle assembly and error correction. Such dual chromatin-microtubule interactions may increase the concentration of the CPC necessary for efficient kinase activity while also making it responsive to specific conditions or structures in the cell. CPC-microtubule dependent functions are considered in the context of the first meiotic division. Acentrosomal spindle assembly is a process that depends on transfer of the CPC from the chromosomes to the microtubules. Furthermore, transfer to the microtubules is not only to position the CPC for a later role in cytokinesis; metaphase I error correction and subsequent bi-orientation of bivalents may depend on microtubule associated CPC interacting with the kinetochores.
| Original language | American English |
|---|---|
| Article number | 2100202 |
| Journal | BioEssays |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2022 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
Keywords
- central spindle
- chromosome passenger complex
- chromosome segregation
- kinetochore
- meiosis
- oocyte