Hippo signaling goes long range

Veronica A. Codelia; Kenneth D. Irvine

doi:10.1016/j.cell.2012.07.020

Hippo signaling goes long range

Veronica A. Codelia, Kenneth D. Irvine

Rutgers, The State University

Research output: Contribution to journal › Short survey › peer-review

22 Scopus citations

Abstract

The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

Original language	American English
Pages (from-to)	669-670
Number of pages	2
Journal	Cell
Volume	150
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2012.07.020
State	Published - Aug 17 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2012.07.020

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title = "Hippo signaling goes long range",

abstract = "The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.",

author = "Codelia, {Veronica A.} and Irvine, {Kenneth D.}",

year = "2012",

month = aug,

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doi = "10.1016/j.cell.2012.07.020",

language = "American English",

volume = "150",

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journal = "Cell",

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T1 - Hippo signaling goes long range

AU - Codelia, Veronica A.

AU - Irvine, Kenneth D.

PY - 2012/8/17

Y1 - 2012/8/17

N2 - The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

AB - The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

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U2 - 10.1016/j.cell.2012.07.020

DO - 10.1016/j.cell.2012.07.020

M3 - Short survey

C2 - 22901800

SN - 0092-8674

VL - 150

SP - 669

EP - 670

JO - Cell

JF - Cell

IS - 4

ER -

Hippo signaling goes long range

Abstract

ASJC Scopus subject areas

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