Hiv-1 Infection Of First-Trimester And Term Human Placental Tissue: A Possible Mode Of Maternal-Fetal Transmission

Wendy Maury, Barbara J. Potts, Arnold B. Rabson

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

To understand the potential role of placental tissue in the pathogenesis of neonatal AIDS, the distribution of human immunodeficiency virus type 1 (HIV-1) receptor and the infec- tability of placental tissue by HIV-1 were studied. Both the mRNA and the protein for the HIV receptor (CD4) were present in fetal-derived placenta. By immunofluorescent microscopy, a number of different cell types appeared to be CD4+; positive cells were observed in the lining and stroma of the chorionic villi. Some of these CD44 cells dual-labeled with the trophoblastic marker placental lactogen. In addition, CD4+ cells were observed within the lining of placental blood vessels. Organ cultures of first-trimester and term placentas were infectable by HIV as monitored by reverse transcriptase activity of culture supernatants and by immunofluorescent labeling of HIV antigens. One potential route of congenital HIV transmission may be direct placental infection by HIV as early as the first trimester, with subsequent transplacental spread of the virus.

Original languageEnglish (US)
Pages (from-to)583-588
Number of pages6
JournalJournal of Infectious Diseases
Volume160
Issue number4
DOIs
StatePublished - Oct 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy

Fingerprint

Dive into the research topics of 'Hiv-1 Infection Of First-Trimester And Term Human Placental Tissue: A Possible Mode Of Maternal-Fetal Transmission'. Together they form a unique fingerprint.

Cite this