HMGI Family Proteins: Architectural Transcription Factors in Mammalian Development and Cancer

Xianjin Zhou, Kiran Chada

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The HMGI proteins, a subfamily of the high mobility group (HMG) proteins, play an important role in the regulation of gene expression. They bind to AT-rich DNA sequences and alter DNA conformation to modulate the binding affinity of transcription factors to their cognate sites. They are expressed almost exclusively during embryogenesis and Hmgi-c null mice have the mouse pygmy phenotype. Studies have revealed the disruption of HMGI family genes in a variety of mesenchymal-derived benign tumors. Therefore, the HMGI genes function in the coordination of cell proliferation and differentiation during mammalian development.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalKeio Journal of Medicine
Volume47
Issue number2
DOIs
StatePublished - Jun 1998

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Architectural transcription factors
  • Cancer
  • Development
  • HMGI

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