Hydration and partial compressibility of biological compounds

Tigran V. Chalikian, Armen P. Sarvazyan, Kenneth Breslauer

Research output: Contribution to journalReview article

222 Citations (Scopus)

Abstract

We review the results of compressibility studies on proteins, nucleic acids, and systematically altered low molecular weight compounds that model the constituents of these biopolymers. The model compound data allow one to define the compressibility properties of water surrounding charged, polar, and nonpolar groups. These results, in conjunction with compressibility data on proteins and nucleic acids, were used to define the properties of water that is perturbed by the presence of these biopolymers in aqueous solutions. Throughout this review, we emphasize the importance of compressibility data for characterizing the hydration properties of solutes (particularly, proteins, nucleic acids, and their constituents), while describing how such data can be interpreted to gain insight into role that hydration can play in modulating the stability of and recognition between biologically important compounds.

Original languageEnglish (US)
Pages (from-to)89-109
Number of pages21
JournalBiophysical chemistry
Volume51
Issue number2-3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Compressibility
Hydration
Nucleic Acids
Biopolymers
Proteins
Water
Molecular Weight
Molecular weight

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Cite this

Chalikian, Tigran V. ; Sarvazyan, Armen P. ; Breslauer, Kenneth. / Hydration and partial compressibility of biological compounds. In: Biophysical chemistry. 1994 ; Vol. 51, No. 2-3. pp. 89-109.
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Hydration and partial compressibility of biological compounds. / Chalikian, Tigran V.; Sarvazyan, Armen P.; Breslauer, Kenneth.

In: Biophysical chemistry, Vol. 51, No. 2-3, 01.01.1994, p. 89-109.

Research output: Contribution to journalReview article

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