Hyperpolarized Porous Silicon Nanoparticles

Potential Theragnostic Material for 29Si Magnetic Resonance Imaging

Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy Son Luu, Shivanand Pudakalakatti, Caitlin McCowan, Yaewon Kim, Niki Zacharias, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.

Original languageEnglish (US)
Pages (from-to)2143-2147
Number of pages5
JournalChemPhysChem
Volume19
Issue number17
DOIs
StatePublished - Sep 5 2018

Fingerprint

Porous silicon
porous silicon
magnetic resonance
Nanoparticles
nanoparticles
Magnetic resonance
Imaging techniques
platforms
Spin-lattice relaxation
Medical imaging
Drug delivery
Silicon Dioxide
spin-lattice relaxation
Magnetic resonance imaging
Relaxation time
Contrast Media
delivery
drugs
relaxation time
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

Cite this

Seo, Hyeonglim ; Choi, Ikjang ; Whiting, Nicholas ; Hu, Jingzhe ; Luu, Quy Son ; Pudakalakatti, Shivanand ; McCowan, Caitlin ; Kim, Yaewon ; Zacharias, Niki ; Lee, Seunghyun ; Bhattacharya, Pratip ; Lee, Youngbok. / Hyperpolarized Porous Silicon Nanoparticles : Potential Theragnostic Material for 29Si Magnetic Resonance Imaging. In: ChemPhysChem. 2018 ; Vol. 19, No. 17. pp. 2143-2147.
@article{9b37066e6afa44f5ada9394a9e217005,
title = "Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29Si Magnetic Resonance Imaging",
abstract = "Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.",
author = "Hyeonglim Seo and Ikjang Choi and Nicholas Whiting and Jingzhe Hu and Luu, {Quy Son} and Shivanand Pudakalakatti and Caitlin McCowan and Yaewon Kim and Niki Zacharias and Seunghyun Lee and Pratip Bhattacharya and Youngbok Lee",
year = "2018",
month = "9",
day = "5",
doi = "https://doi.org/10.1002/cphc.201800461",
language = "English (US)",
volume = "19",
pages = "2143--2147",
journal = "ChemPhysChem",
issn = "1439-4235",
publisher = "Wiley-VCH Verlag",
number = "17",

}

Seo, H, Choi, I, Whiting, N, Hu, J, Luu, QS, Pudakalakatti, S, McCowan, C, Kim, Y, Zacharias, N, Lee, S, Bhattacharya, P & Lee, Y 2018, 'Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29Si Magnetic Resonance Imaging', ChemPhysChem, vol. 19, no. 17, pp. 2143-2147. https://doi.org/10.1002/cphc.201800461

Hyperpolarized Porous Silicon Nanoparticles : Potential Theragnostic Material for 29Si Magnetic Resonance Imaging. / Seo, Hyeonglim; Choi, Ikjang; Whiting, Nicholas; Hu, Jingzhe; Luu, Quy Son; Pudakalakatti, Shivanand; McCowan, Caitlin; Kim, Yaewon; Zacharias, Niki; Lee, Seunghyun; Bhattacharya, Pratip; Lee, Youngbok.

In: ChemPhysChem, Vol. 19, No. 17, 05.09.2018, p. 2143-2147.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hyperpolarized Porous Silicon Nanoparticles

T2 - Potential Theragnostic Material for 29Si Magnetic Resonance Imaging

AU - Seo, Hyeonglim

AU - Choi, Ikjang

AU - Whiting, Nicholas

AU - Hu, Jingzhe

AU - Luu, Quy Son

AU - Pudakalakatti, Shivanand

AU - McCowan, Caitlin

AU - Kim, Yaewon

AU - Zacharias, Niki

AU - Lee, Seunghyun

AU - Bhattacharya, Pratip

AU - Lee, Youngbok

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.

AB - Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.

UR - http://www.scopus.com/inward/record.url?scp=85052784335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052784335&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/cphc.201800461

DO - https://doi.org/10.1002/cphc.201800461

M3 - Article

VL - 19

SP - 2143

EP - 2147

JO - ChemPhysChem

JF - ChemPhysChem

SN - 1439-4235

IS - 17

ER -