Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation

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Although Helicobacter pylori is now recognized as playing an etiologic role in chronic gastritis and peptic ulcer disease, information on the pathogenesis and natural history of infection is limited. A model is proposed in which luminal H. pylori secrete substances that mediate inflammation that is beneficial to the organism but ultimately deleterious for the host; in addition to tissue damage, inflammation also affects gastric secretory function. In this model, the host may attempt to suppress the inflammatory response, and the adequacy of this postulated down-regulation determines pathological and clinical outcome. The effects of the inflammatory process on gastrin-hydrochloric acid homeostasis may be of critical importance in the pathogenesis of peptic ulcer disease. Because the long-term consequences of H. pylori colonization reflect the continued presence of the organism in the host over years or decades, it may be useful to consider this as a "slow" bacterial infection.

Original languageEnglish (US)
Pages (from-to)720-727
Number of pages8
Issue number2
StatePublished - Feb 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology


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