Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord

Tong Liu; K. Christian Donahue; Jun Hu; Michael P. Kurnellas; Jennifer E. Gran; Hong Li; Stella Elkabes

doi:10.1021/pr070012k

Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord

Tong Liu, K. Christian Donahue, Jun Hu, Michael P. Kurnellas, Jennifer E. Gran, Hong Li, Stella Elkabes

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.

Original language	American English
Pages (from-to)	2565-2575
Number of pages	11
Journal	Journal of Proteome Research
Volume	6
Issue number	7
DOIs	https://doi.org/10.1021/pr070012k
State	Published - Jul 2007

ASJC Scopus subject areas

General Chemistry
Biochemistry

Keywords

EAE
Mass spectrometry
Multiple sclerosis
Spinal cord
iTRAQ

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10.1021/pr070012k

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abstract = "The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.",

keywords = "EAE, Mass spectrometry, Multiple sclerosis, Spinal cord, iTRAQ",

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AU - Gran, Jennifer E.

AU - Li, Hong

AU - Elkabes, Stella

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AB - The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.

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KW - Mass spectrometry

KW - Multiple sclerosis

KW - Spinal cord

KW - iTRAQ

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Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord

Abstract

ASJC Scopus subject areas

Keywords

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