Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord

Tong Liu, K. Christian Donahue, Jun Hu, Michael P. Kurnellas, Jennifer E. Gran, Hong Li, Stella Elkabes

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.

Original languageEnglish (US)
Pages (from-to)2565-2575
Number of pages11
JournalJournal of Proteome Research
Volume6
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

Keywords

  • EAE
  • Mass spectrometry
  • Multiple sclerosis
  • Spinal cord
  • iTRAQ

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