Impact of phenotypic rapid diagnostic assay on duration of empiric antibiotics for gram-negative bacteremia

Sana M. Mohayya, Mohammad Arsalan, Navaneeth Narayanan, Purvi Patel, Christin G. Hong, Thomas J. Kirn, Pinki J. Bhatt, Tanaya Bhowmick

Research output: Contribution to journalArticlepeer-review


Objective: Rapid diagnostic tests (RDTs) are increasingly being implemented as antimicrobial stewardship tools to facilitate antibiotic modification and reduce complications related to their overutilization. We measured the clinical impact of a phenotypic RDT with antimicrobial stewardship (AMS) in the setting of gram-negative bacteremia. Setting and participants: In this single-center retrospective cohort study, we evaluated adult patients with gram-negative bacteremia who received at least 72 hours of an antibiotic. Methods: The primary outcome was the duration of empiric antibiotic therapy for gram-negative bacteremia. Secondary outcomes included time-to-directed therapy, proportion of modifications, hospital length of stay (LOS), and subsequent infection with a multidrug-resistant organism (MDRO) or C. difficile infection (CDI). Results: The duration of empiric antibiotics decreased in the RDT+AMS group (4 days vs 2 days; P <.01). Time to directed therapy decreased from 75.0 to 27.9 hours (P <.01). Conclusions: The clinical outcomes of LOS, MDRO, and CDI were reduced. The phenotypic RDT demonstrated an improvement in stewardship measures and clinical outcomes.

Original languageAmerican English
Article numbere22
JournalAntimicrobial Stewardship and Healthcare Epidemiology
Issue number1
StatePublished - Jan 30 2023
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology


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