Abstract
The effect of the pressure-volume (P-V) curve of the large arteries on systemic blood pressure was studied using a closed-loop model of the cardiovascular system. Three types of P-V alterations were considered: constant compliance with altered unstressed volume, compliance change, and nonlinear P-V with altered unstressed volume. It was found that a compliance change or P-V curve shift are not only equally capable of affecting average blood pressure, but also affect pulse pressure. The nonlinear P-V relationship with P-V shift most resembled hypertension and was highly effective in achieving elevated pressures and pulse pressure. Further, it was observed that peripheral resistance is only required to change when cardiac output was restored to pre-altered pressure levels.
| Original language | American English |
|---|---|
| Pages (from-to) | 52-60 |
| Number of pages | 9 |
| Journal | Unknown Journal |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1999 |
ASJC Scopus subject areas
- Modeling and Simulation
- General Mathematics
- Mechanics of Materials
- General Engineering
- Hardware and Architecture
- Industrial and Manufacturing Engineering
- Electrical and Electronic Engineering