Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Julie L. Eiseman, Lihua Bai, Won Hyuk Jung, Gustavo Moura-Letts, Billy W. Day, Dennis P. Curran

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

Original languageEnglish (US)
Pages (from-to)6650-6653
Number of pages4
JournalJournal of Medicinal Chemistry
Volume51
Issue number21
DOIs
StatePublished - Nov 13 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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