In vitro analysis of a tissue-engineered anterior cruciate ligament scaffold

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Anterior cruciate ligament (ACL) reconstruction surgery currently relies on the use of autograft and allograft tissue. Challenges facing these treatments, such as donor site morbidity and risk of disease transmission, have encouraged the pursuit of viable alternatives. Degradable polymer scaffolds offer an alternative to available treatment options by providing an "off the shelr' solution. Initially, the scaffold serves to stabilize the knee and function as a framework for host tissue infiltration. As resorption follows, the load is transferred from the degrading scaffold to the developing neoligament tissue. The objective of this study is to investigate the potential of a silk-collagen hybrid fiber scaffold as a ligament replacement device. In vitro tensile testing and cell proliferation studies favor the use of a high silk to collagen ratio for an optimal combination of mechanics and biological response. These preliminary results suggest that a silk-collagen scaffold has the mechanical strength and cell seeding ability necessary to potentially serve as an ACL replacement device.

Original languageEnglish (US)
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
DOIs
StatePublished - 2009
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: Apr 3 2009Apr 5 2009

Publication series

NameBioengineering, Proceedings of the Northeast Conference

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Country/TerritoryUnited States
CityBoston, MA
Period4/3/094/5/09

ASJC Scopus subject areas

  • Bioengineering

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