In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

Barry Cense, Teresa C. Chen, B. Hyle Park, Mark Pierce, Johannes F. De Boer

Research output: Contribution to journalConference article

Abstract

We present in vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, co-registered with video images of the location of PS-OCT scans on the retina. Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL varies with location with values in between 0.18 and 0.37°/μm. A trend in the preliminary measurements shows that thicker nerve fiber layer tissue is more birefringent than thin nerve fiber layer tissue.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4951
DOIs
StatePublished - Dec 5 2003
Externally publishedYes
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Opthalmic Technologies XIII - San Jose, CA, United States
Duration: Jan 25 2003Jan 26 2003

Fingerprint

nerve fibers
Optical Coherence Tomography
Optical tomography
Birefringence
Nerve
birefringence
Polarization
tomography
Fiber
Fibers
glaucoma
polarization
retina
Retina
Tissue
causes
Human
damage
trends
Damage

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Applied Mathematics
  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

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abstract = "We present in vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, co-registered with video images of the location of PS-OCT scans on the retina. Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL varies with location with values in between 0.18 and 0.37°/μm. A trend in the preliminary measurements shows that thicker nerve fiber layer tissue is more birefringent than thin nerve fiber layer tissue.",
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In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography. / Cense, Barry; Chen, Teresa C.; Park, B. Hyle; Pierce, Mark; De Boer, Johannes F.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 4951, 05.12.2003, p. 27-31.

Research output: Contribution to journalConference article

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AU - Cense, Barry

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