Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling

S. H. Manes, G. J. Pruss, K. Drlica

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Oxolinic acid reduced RNA synthesis rates whether chromosome supercoiling decreased, increased, or remained unchanged. Thus, inhibition of RNA synthesis by oxolinic acid appears to involve factors other than average DNA supercoiling level. Coumermycin A1 caused RNA synthesis rates to increase or decrease roughly in parallel with DNA supercoiling.

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalJournal of bacteriology
Volume155
Issue number1
StatePublished - 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Microbiology

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