Inhibitory effects of grape seed extract on lipases

Diego A. Moreno, Nebojsa Ilic, Alexander Poulev, Susan K. Fried, Ilya Raskin

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

OBJECTIVE: The aim of the present study was to assess the effects of grape seed extract (GSE) on the fat-metabolizing enzymes pancreatic lipase, lipoprotein lipase, and hormone-sensitive lipase in vitro and evaluate its potential application as a treatment for obesity. METHODS: Crushed grape seeds were extracted in ethanol, and the extract was assayed for the measurement of inhibitory effects on pancreatic lipase and lipoprotein lipase activities and on lipolysis of 3T3-L1 adipocytes. RESULTS: The GSE rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase, thus suggesting that GSE might be useful as a treatment to limit dietary fat absorption and the accumulation of fat in adipose tissue. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids that have been linked to insulin resistance in obese patients. CONCLUSION: The GSE rich in compounds that inhibit lipases may provide a safe, natural, and cost-effective weight control treatment.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalNutrition
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2003

Fingerprint

Grape Seed Extract
Lipase
Lipoprotein Lipase
Fats
Adipocytes
Sterol Esterase
Lipolysis
Dietary Fats
Vitis
Phytochemicals
Enzymes
Nonesterified Fatty Acids
Insulin Resistance
Adipose Tissue
Seeds
Ethanol
Therapeutics
Obesity
Weights and Measures
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Keywords

  • Natural products
  • Obesity
  • Plant extracts
  • Vitis vinifera

Cite this

Moreno, Diego A. ; Ilic, Nebojsa ; Poulev, Alexander ; Fried, Susan K. ; Raskin, Ilya. / Inhibitory effects of grape seed extract on lipases. In: Nutrition. 2003 ; Vol. 19, No. 10. pp. 876-879.
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Moreno, DA, Ilic, N, Poulev, A, Fried, SK & Raskin, I 2003, 'Inhibitory effects of grape seed extract on lipases', Nutrition, vol. 19, no. 10, pp. 876-879. https://doi.org/10.1016/S0899-9007(03)00167-9

Inhibitory effects of grape seed extract on lipases. / Moreno, Diego A.; Ilic, Nebojsa; Poulev, Alexander; Fried, Susan K.; Raskin, Ilya.

In: Nutrition, Vol. 19, No. 10, 01.10.2003, p. 876-879.

Research output: Contribution to journalArticle

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AU - Moreno, Diego A.

AU - Ilic, Nebojsa

AU - Poulev, Alexander

AU - Fried, Susan K.

AU - Raskin, Ilya

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N2 - OBJECTIVE: The aim of the present study was to assess the effects of grape seed extract (GSE) on the fat-metabolizing enzymes pancreatic lipase, lipoprotein lipase, and hormone-sensitive lipase in vitro and evaluate its potential application as a treatment for obesity. METHODS: Crushed grape seeds were extracted in ethanol, and the extract was assayed for the measurement of inhibitory effects on pancreatic lipase and lipoprotein lipase activities and on lipolysis of 3T3-L1 adipocytes. RESULTS: The GSE rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase, thus suggesting that GSE might be useful as a treatment to limit dietary fat absorption and the accumulation of fat in adipose tissue. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids that have been linked to insulin resistance in obese patients. CONCLUSION: The GSE rich in compounds that inhibit lipases may provide a safe, natural, and cost-effective weight control treatment.

AB - OBJECTIVE: The aim of the present study was to assess the effects of grape seed extract (GSE) on the fat-metabolizing enzymes pancreatic lipase, lipoprotein lipase, and hormone-sensitive lipase in vitro and evaluate its potential application as a treatment for obesity. METHODS: Crushed grape seeds were extracted in ethanol, and the extract was assayed for the measurement of inhibitory effects on pancreatic lipase and lipoprotein lipase activities and on lipolysis of 3T3-L1 adipocytes. RESULTS: The GSE rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase, thus suggesting that GSE might be useful as a treatment to limit dietary fat absorption and the accumulation of fat in adipose tissue. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids that have been linked to insulin resistance in obese patients. CONCLUSION: The GSE rich in compounds that inhibit lipases may provide a safe, natural, and cost-effective weight control treatment.

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