Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In this article, Levison, Wood and colleagues demonstrate that IGF-II expression in the adult mouse is necessary for maintaining multiple adult stem cell niches including in the subventricular and subgranular zones of the brain and in the crypts of Lieberkühn of the gut.

Original languageEnglish (US)
Pages (from-to)816-830
Number of pages15
JournalStem Cell Reports
Volume12
Issue number4
DOIs
StatePublished - Apr 9 2019

All Science Journal Classification (ASJC) codes

  • Genetics
  • Biochemistry
  • Cell Biology
  • Developmental Biology

Keywords

  • IGF-II
  • crypt of Lieberkühn
  • intestinal stem cell
  • neural stem cell
  • neurogenesis
  • subgranular zone
  • subventricular zone

Fingerprint Dive into the research topics of 'Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine'. Together they form a unique fingerprint.

  • Cite this

    Ziegler, A. N., Feng, Q., Chidambaram, S., Testai, J. M., Kumari, E., Rothbard, D. E., Constancia, M., Sandovici, I., Cominski, T., Pang, K., Gao, N., Wood, T. L., & Levison, S. W. (2019). Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports, 12(4), 816-830. https://doi.org/10.1016/j.stemcr.2019.02.011