Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

Hyung J. Ahn; Zu Lin Chen; Daria Zamolodchikov; Erin H. Norris; Sidney Strickland

doi:10.1097/MOH.0000000000000368

Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

Hyung J. Ahn
, Zu Lin Chen
, Daria Zamolodchikov
, Erin H. Norris
, Sidney Strickland

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.

Original language	American English
Pages (from-to)	427-431
Number of pages	5
Journal	Current Opinion in Hematology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1097/MOH.0000000000000368
State	Published - Sep 1 2017
Externally published	Yes

ASJC Scopus subject areas

Hematology

Keywords

Alzheimer's disease
factor XII
fibrinogen
β-amyloid peptide

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10.1097/MOH.0000000000000368

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title = "Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease",

abstract = "To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.",

keywords = "Alzheimer's disease, factor XII, fibrinogen, β-amyloid peptide",

author = "Ahn, \{Hyung J.\} and Chen, \{Zu Lin\} and Daria Zamolodchikov and Norris, \{Erin H.\} and Sidney Strickland",

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T1 - Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

AU - Ahn, Hyung J.

AU - Chen, Zu Lin

AU - Zamolodchikov, Daria

AU - Norris, Erin H.

AU - Strickland, Sidney

PY - 2017/9/1

Y1 - 2017/9/1

N2 - To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.

AB - To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.

KW - Alzheimer's disease

KW - factor XII

KW - fibrinogen

KW - β-amyloid peptide

UR - https://www.scopus.com/pages/publications/85021678285

UR - https://www.scopus.com/pages/publications/85021678285#tab=citedBy

U2 - 10.1097/MOH.0000000000000368

DO - 10.1097/MOH.0000000000000368

M3 - Review article

C2 - 28661939

SN - 1065-6251

VL - 24

SP - 427

EP - 431

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

IS - 5

ER -

Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

Abstract

ASJC Scopus subject areas

Keywords

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