Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I

Vasileios Kokkinos

doi:10.1097/WNP.0000000000001104

Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I

Vasileios Kokkinos

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging. Methods: Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level–dependent changes in the whole-brain volume. Results: In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level–dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients’ typical interictal activity. Conclusions: The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.

Original language	American English
Pages (from-to)	287-293
Number of pages	7
Journal	Journal of Clinical Neurophysiology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1097/WNP.0000000000001104
State	Published - May 1 2025
Externally published	Yes

ASJC Scopus subject areas

Physiology
Neurology
Clinical Neurology
Physiology (medical)

Keywords

Anterior cingulate
Electroencephalography
Functional magnetic resonance imaging
Hypermotor seizures
Ictal semiology
Superior frontal gyrus

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10.1097/WNP.0000000000001104

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title = "Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I",

abstract = "Purpose: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging. Methods: Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level–dependent changes in the whole-brain volume. Results: In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level–dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients{\textquoteright} typical interictal activity. Conclusions: The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.",

keywords = "Anterior cingulate, Electroencephalography, Functional magnetic resonance imaging, Hypermotor seizures, Ictal semiology, Superior frontal gyrus",

author = "Vasileios Kokkinos",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 by the American Clinical Neurophysiology Society.",

year = "2025",

month = may,

day = "1",

doi = "10.1097/WNP.0000000000001104",

language = "American English",

volume = "42",

pages = "287--293",

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AU - Kokkinos, Vasileios

PY - 2025/5/1

Y1 - 2025/5/1

N2 - Purpose: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging. Methods: Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level–dependent changes in the whole-brain volume. Results: In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level–dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients’ typical interictal activity. Conclusions: The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.

AB - Purpose: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging. Methods: Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level–dependent changes in the whole-brain volume. Results: In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level–dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients’ typical interictal activity. Conclusions: The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.

KW - Anterior cingulate

KW - Electroencephalography

KW - Functional magnetic resonance imaging

KW - Hypermotor seizures

KW - Ictal semiology

KW - Superior frontal gyrus

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Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I

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ASJC Scopus subject areas

Keywords

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