Intrauterine growth retardation as an endpoint in mutation epidemiology: an evaluation based on paternal age

TY - JOUR

T1 - Intrauterine growth retardation as an endpoint in mutation epidemiology

T2 - an evaluation based on paternal age

AU - Olshan, Andrew F.

AU - Ananth, Cande V.

AU - Savitz, David A.

PY - 1995/8

Y1 - 1995/8

N2 - Czeizel recently suggested that intrauterine growth retardation might be of value as a phenotypic endpoint in mutation epidemiology. We hypothesized that if some fraction of small-for-gestational age (SGA) births are due to new germinal mutations, then an association with advanced paternal age should be present. We evaluated the relation between paternal age and SGA, low birthweight, and preterm births using a large sample of births (n = 254,892) from North Carolina. The analyses were restricted to births of mothers aged 20-34 years and adjusted for maternal age, race, education, marital status, gravidity, and smoking. No material increase in the risk of SGA, low birthweight, and preterm delivery was found for fathers in any age category. For example, odds ratios for SGA ranged from 0.87 (fathers aged 50 years or greater) to 1.13 (fathers aged 45-49 years). The results indicate no discernable relationship between SGA and related endpoints and the increase in increase mutations that accompany advanced paternal age.

AB - Czeizel recently suggested that intrauterine growth retardation might be of value as a phenotypic endpoint in mutation epidemiology. We hypothesized that if some fraction of small-for-gestational age (SGA) births are due to new germinal mutations, then an association with advanced paternal age should be present. We evaluated the relation between paternal age and SGA, low birthweight, and preterm births using a large sample of births (n = 254,892) from North Carolina. The analyses were restricted to births of mothers aged 20-34 years and adjusted for maternal age, race, education, marital status, gravidity, and smoking. No material increase in the risk of SGA, low birthweight, and preterm delivery was found for fathers in any age category. For example, odds ratios for SGA ranged from 0.87 (fathers aged 50 years or greater) to 1.13 (fathers aged 45-49 years). The results indicate no discernable relationship between SGA and related endpoints and the increase in increase mutations that accompany advanced paternal age.

KW - Epidemiology

KW - Father

KW - Low birth weight

KW - Mutation

UR - https://www.scopus.com/pages/publications/0029150380

UR - https://www.scopus.com/pages/publications/0029150380#tab=citedBy

U2 - 10.1016/0165-1218(95)90043-8

DO - 10.1016/0165-1218(95)90043-8

M3 - Article

C2 - 7565898

SN - 0165-1218

VL - 344

SP - 89

EP - 94

JO - Mutation Research/Genetic Toxicology

JF - Mutation Research/Genetic Toxicology

IS - 1-2

ER -