Laminins in basement membrane assembly

Erhard Hohenester, Peter D. Yurchenco

Research output: Contribution to journalReview article

184 Scopus citations

Abstract

The heterotrimeric laminins are a defining component of all basement membranes and self-assemble into a cell-associated network. The three short arms of the cross-shaped laminin molecule form the network nodes, with a strict requirement for one α, one β and one γ arm. The globular domain at the end of the long arm binds to cellular receptors, including integrins, α-dystroglycan, heparan sulfates and sulfated glycolipids. Collateral anchorage of the laminin network is provided by the proteoglycans perlecan and agrin. A second network is then formed by type IV collagen, which interacts with the laminin network through the heparan sulfate chains of perlecan and agrin and additional linkage by nidogen. This maturation of basement membranes becomes essential at later stages of embryo development.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalCell Adhesion and Migration
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Keywords

  • Agrin
  • Collagen IV
  • Dystroglycan
  • Laminin
  • Nidogen
  • Perlecan

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